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pentobarbital increases toxicity of buprenorphine, long-performing injection by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of buprenorphine and benzodiazepines or other CNS depressants increases threat of adverse reactions together with overdose, respiratory despair, and Demise. Cessation of benzodiazepines or other CNS depressants is preferred in most cases.
pentobarbital increases effects of ifosfamide by affecting hepatic enzyme CYP2B6 metabolism. Use Caution/Keep track of. Coadministration of ifosfamide with CYP2B6 inducers may possibly maximize metabolism of ifosfamide to its metabolite. Keep track of for improved effects/toxicities if put together with CYP2B6 inducers.
pentobarbital will increase toxicity of ifosfamide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. CYP3A4 inducers may enhance the metabolism of ifosfamide to its Energetic alkylating metabolites.
fentanyl transmucosal and pentobarbital the two boost sedation. Steer clear of or Use Alternate Drug. Limit use to people for whom alternate procedure selections are inadequate
pentobarbital will minimize the extent or result of bazedoxifene/conjugated estrogens by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
Pursuing oral or parenteral administration, barbiturates easily cross the placental barrier and they are dispersed all through fetal tissues with best concentrations found in the placenta, fetal liver, and brain; fetal blood stages approach maternal blood ranges pursuing parenteral administration
pentobarbital will decrease the extent or result of netupitant/palonosetron by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Netupitant is especially metabolized by CYP3A4; keep away from use in individuals who will be chronically employing get more info a strong CYP3A4 inducer
pentobarbital will decrease the extent or influence of maraviroc by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
pentobarbital will decrease the level or impact of piroxicam by affecting hepatic enzyme CYP2C9/10 metabolism. Small/Significance Unidentified.
pentobarbital will reduce the extent or result of celecoxib by affecting hepatic enzyme CYP2C9/10 metabolism. Insignificant/Importance Unidentified.
Contraindicated. Coadministration of lorlatinib with sturdy CYP3A inducers is contraindicated. Discontinue the solid CYP3A inducer for three plasma 50 percent-lives ahead of initiating lorlatinib.
pentobarbital will lower the level or result of fludrocortisone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
pentobarbital will minimize the level or effect of rolapitant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Extensive-term coadministration of sturdy CYP3A4 inducers with rolapitant might noticeably reduce rolapitant efficacy.
pentobarbital will minimize the level or impact of paclitaxel by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Not known.